Abstract The hypoxic microenvironment is presumed to be a sanctuary for myeloid leukemia cells that causes relapse following chemotherapy. but the underlying mechanism remains elusive. Using a zebrafish xenograft model. we observed that the hypoxic hematopoietic tissue preserved most of the chemoresistant leukemic cells following the doxorubicin (Dox) treatment. https://parisnaturalfoodes.shop/product-category/kwan-loong-oil/