BackgroundTNF-related lymphotoxin alpha (LTalpha) is essential for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM). The pathway involved has been attributed to TNFR2. Here we show a second arm of LTalpha-signaling essential for ECM development through LTbeta-R. receptor of LTalpha1beta2 heterotrimer. https://herbsdailyes.shop/product-category/proline-l-proline/
Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria.
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