Abstract Lateral hypothalamic (LH) hypocretin/orexin neurons (HONs) control brain-wide electrical excitation. Abnormally high excitation produces epileptic seizures. which affect millions of people and need better treatments. HON population activity spikes from minute to minute. https://www.roneverhart.com/SWW-x-SXSW-Cake-Something-Was-Wrong-2-8x3/