Genetic defects affecting the remethylation pathway cause hyperhomocysteinemia. Isolated remethylation defects are caused by mutations of the 5. 10-methylenetetrahydrofolate reductase (MTHFR) . methionine synthase reductase (MTRR) . https://www.hindigyanvishv.com/hot-find-Facia-Installation-Kit-Suits-Holden-Commodore-VE-Series-2-FP9550BK-Black-top-mega/