Metabolic Alterations associated with T2D are very well characterised by epidemiological and research based mostly studies. The pathogenesis and development of T2D is ascribed to 4 mechanisms; increased Innovative glycation conclusion merchandise (AGE) formation, enhanced polyol pathway flux, activation of protein kinase C (PKC) isoforms, and enhanced hexosamine pathway flux[seven]. https://www.directivepublications.org/journal-of-diabetology-research/